Adderall and Ritalin: With Heart Risks Uncertain, What Should Patients Do?

Some Medical Advice About ADHD/ADD Drugs From Cardiologists And Psychiatrists

In mid-February 2006 came the news that an advisory panel of drug-safety experts recommended a "black-box" warning for Adderall, Ritalin, and the other ADHD/ADD drugs — and that the FDA was not going to act on this advice, at least for the time being.  This situation left many people understandably confused.

To address some of these concerns and questions, New York Times (NYT) reporter Benedict Carey interviewed some prominent cardiologists and psychiatrists (free registration required) for an article which was published on February 21, 2006.  Mr. Carey’s apparent aim was to provide some guidance to adult patients and the parents of pediatric patients in terms of how to proceed in view of the possible serious side effects associated with Adderall, Ritalin, and the other ADHD/ADD drugs.  Here is a summary of his findings.

Primarily, it is people with high blood pressure, heart murmurs, or other cardiovascular problems who should be consulting with their doctors in order to determine whether Adderall, Ritalin, or some other ADHD/ADD drug is safe for them. 

Along these line, concerning pediatric patients, Mr. Carey reports:

Some panel members expressed concerns about children with structural heart abnormalities who might be given stimulants. Perhaps the most common abnormality is hypertrophic obstructive cardiomyopathy, a thickening of the muscle that can cause a blockage — and death — when under stress.

Such problems are often not diagnosed before drug treatment begins, but a good pediatrician who is aware a child is being considered for stimulant treatment will often pick up a soft heart murmur that might reflect an abnormality, said Dr. Steven Nissen, chief of cardiology at the Cleveland Clinic and a panel member. "This seemingly small step could save a life," he said.

As for adult patients using Adderall or Ritalin, the emphasis is on one’s blood pressure. From Mr. Carey’s February 21 NYT article:

The biggest worry for adults is high blood pressure. Stimulants usually prompt slight increases in heart rate and raise blood pressure, and even these changes can increase the risk of heart problems in someone who is vulnerable, Dr. Nissen said.

"A smoker with high cholesterol and a family history of heart disease: that’s a person I would be very concerned about taking stimulants," Dr. Nissen said.

From his interviews, Mr. Carey found that, generally, there are a few screening questions which would help a doctor determine whether or not Adderall or Ritalin is safe for a patient.

  • Are there any congenital or structural heart defects?
  • Are there unexplained bouts of dizziness or heart palpitations?
  • Is there any family history of heart disease, in particular sudden deaths in close relatives who died young?

It seems advisable that doctors should be these few questions, at least, before prescribing Adderall, Ritalin, or another ADHD/ADD medication.  If your doctor, or your child’s doctor, is considering such treatments but has not asked, you should "volunteer" this part of your medical history for their decision-making.

(Posted by: Tom Lamb)

13 responses to “Adderall and Ritalin: With Heart Risks Uncertain, What Should Patients Do?”

  1. susan gaines Avatar
    susan gaines

    My daughter, now 18 started Adderal in the 8th grade. She’s has suffered headaches, chest pain, stomach pain and feeling so bad that she curles up into a ball and can’t function.
    The Dr thought food algeries, migraines, stress and just in her head as the causes of her problems.
    We just found out that she had Postural
    Orthostatic Techycardia Syndrome. This is what has been causing her extreme problems. She is off the medication & the symptoms are not as severe, but this seems like it is going to be a lasting problem. We have an apt with a nuroligist the end of May and hope to get better news, but do you have any idea if others have suffered this condition due to ADD medicines. They said this can also be passed on from mother to daughter, but I have never had a problem, so it looks like the medicine might be the cause. I would appreciate some feedback…..Thank you

  2. Tom Lamb Avatar

    I have not seen this precise diagnosis in connection with Adderall use, but I have not looked for that diagnosis in particular.
    Here is a link to the briefing materials used by the FDA advisory panel in their February 2006 meetings about the ADHD/ADD drugs:
    http://www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4202_00_TOC.htm
    Perhaps you will find mention of this paricular diagnosis in these materials.
    I wish you and your daughter the best.
    Thanks for reading Drug Injury Watch.
    Tom Lamb

  3. saiga hardigo Avatar
    saiga hardigo

    My nephew who was 18. Just died from an unexplained cariac death or a fatal arrythmia. At first it appeared that he had over dosed on a recreational drug. The autopsie report showed signs of long term high blood pressure in the form of an enlarged left ventrical. He also had high liver enzymes. He has been on the highest dosage of Adderall since it was available. The coroner thinks his cariac problems and death were a result of being on Adderall (amphetamine), which raises your blood pressure. He did experience chest pain while on Adderall. This was said to be a normal side effect.

  4. Eric McBride Avatar
    Eric McBride

    I am 24 and was recently prescribed Ritalin SR 20mg up to twice a day, as needed. It has been known that I have ADD for about 4.5 years.
    I noticed after taking Ritalin for a week (with maybe a rest day here or there) that I began to feel “heavy heart” or general discomfort of the heart.
    I would be scared and stop. This has happened 5 times, each time I consult with my Psyciatrist and GP and other reasons are put forward.
    The last time it happened the “heavy tired heart” feeling didn’t go away fro 3 days, and about 3 hours after I had taken my 2nd dose, I had alittle trouble breathing.
    After taking Ritalin at any time, my heartrate stays at 100+ for over 5 hours. If I have taken Ritalin a few days in a row, when I wake up from a deep sleep I notice a 60BPM arrhythmia.
    I’ve had blood tests and 2 ECGs and XRays. The ER says my heart and lungs are in perfect health as of last week.
    Everyone is saying anxiety attack, stress and GI problems.
    My un-stimulated blood pressure is 112-76, bloodwork is normal, no family history of any heart problems whatsoever.
    The weird feeling is clearly caused by taking the Ritalin. I am convinced. How do I trust this drug and my doctors?! Am I supposed to chill out and get an ECG next year?

  5. Missy Watson Avatar
    Missy Watson

    My late husband died suddenly (during sleep) at the age of 37 of hypertrophic cardiomyopathy. The autopsy showed that the septum of his heart was enlarged. There were no previous symptoms and no family history of this specifically, but there is other heart disease. Although I believe now that he had Sleep Apnea that was never diagnosed, the Dr. that performed the autopsy believed it could have contributed to but not caused the HCM but also said the HCM was not necessarily genetic since there is no history of early sudden death. But, he was prescribed Ritalin at the age of 8 for being hyper. He stopped taking it on his own around 15-16 years old. Could there be a link 20 years later? I thank you for any information you may be able to share.

  6. Kaitlyn Avatar
    Kaitlyn

    My son was prescribed 120 mg of Adderall XR per day with a known diagnosis of Anxiety Disorder. He had to be hospitalized to be tapered off the Adderall.
    Isn’t this “overprescribing?”

  7. Tom Lamb Avatar

    As you can understand, any opinion about the propriety of this prescription must come from a medical doctor, not me as an attorney.
    Best of luck to you and your family.
    Thanks for reading Drug Injury Watch.
    Tom Lamb

  8. Patti Boily Avatar
    Patti Boily

    Yesterday my 27 year old son was told by a cardiologist that he would need open heart surgery to repair his mitral valve – he has left ventricular hypertrophy and a mitral valve that is failing – he had been on Ritalin since he was 15 and continued into adulthood as new information indicated that ADD was not just a childhood disease and that one didn’t necessarily outgrow it.
    He’d been diagnosed at 7 years old with Dyslexia and ADD (not ADHD as there’s never been anything hyper about him – just drifty) and after a trial of Ritalin left him with headaches his father and I declined to continue it, telling the schools they would just have to deal with and accommodate his unique learning style. That worked until teenage angst set in and the feeling was if he could focus more on his schoolwork he’d have more success, blah, blah, blah. A pediatrician who specialized in learning & behavior disabilities started him on Dexadrine but then switched to Ritalin as he was getting too jittery and losing weight.
    When he went to college and on to work the Ritalin seemed to be a necessary part of his focusing and since little kids were often prescribed a much higher dose than he was taking it was felt that it was a pretty inocous drug for a 6’2″, 190# adult.
    Over the years he had a few “warning signs” that there were problems but none of the doctors he saw connected the dots.
    In late summer of 2006 he was having complaints of fatigue, lack of stamina and elevated blood pressure and his family doctor ordered an echocardiogram. It was abnormal but marginally so and the recommendation was that he watch it and make sure he took antibiotics before any dental work.
    As more news was coming out regarding the connection of Ritalin to heart problems his doctors recommended that he stop using it as perhaps it was “driving” his heart too hard.
    A month ago he was visiting friends out of state and had 3-4 episodes of heart wrenching and left arm pain. When he came home he saw his doctor who ordered another echocardiogram and the damage had progressed at an astounding rate – now he is scheduled for a Trans Esophageal Echocardiogram next week as the question is not whether he needs open heart surgery but whether they can repair the valve he has or whether it will need to be replaced.
    Oh, and he doesn’t have any health insurance, isn’t supposed to work more than a few hours a day and shouldn’t lift more than 20# – and if he feels strain or pain he’s supposed to stop whatever it is he’s doing and sit down and rest as there’s a very real chance he could blow out the damaged valve.
    Seems like a pretty high price to pay for good grades.
    Patti
    May 6, 2008

  9. Tom Lamb Avatar

    I appreciate you sharing this background about your son and the news concerning his current medical situation.
    It seems that the ADD/ADHD drugs need to re-examined in terms of prescribing and safety, both.
    If you are interested in some differing views on this issue, there has been a discussion going on the past couple of days over at The Wall Street Journal’s Health Blog, which can be found using this link:
    http://blogs.wsj.com/health/2008/05/05/psychatrists-grumble-about-cardiac-testing-for-adhd-drugs/?mod=WSJBlog
    Thanks for reading Drug Injury Watch.
    Tom Lamb

  10. steph Avatar
    steph

    that is entirely way too much adderall…it is supposed to be prescribed by weight. My boyfriend is 225lbs and they started him on 20mgs and then moved him up to 30mgs. I have never known of anyone being prescribed to more than 40mgs, and thats a high dose…

  11. mmarx7@yahoo.com Avatar
    mmarx7@yahoo.com

    I believe you may not have add? U have anxiety due to overstimulation, people with add have low dopamine levels when they take the meds it restores them to normal but a normal person without add will result in abnormally high levels of neophrine and dopamine which are accosiated with fight of flight and anxiety. But I am not a doctor perhaps u have unrelated anxiety due to incorrect GABA chemical receptors if this is the cause you should talk to ur doctor about taking anti anxiety medicine when you feel these symtoms. But I am not a doctor by any means and this is all personal opinion, do some research and take your health into your own hands.

  12. pippins.girl@yahoo.com Avatar
    pippins.girl@yahoo.com

    i took Ritalin as a teen to help me focus for school and work but stopped taking it when i became a stay at home mom now that my kids are older and i have re-entered the work force i feel the need to begin taking it again but i now have a mitral valve prolapse and an “herbs” heart murmur from having scarlet fever as a child – Is this a reason to not take stimulants and just deal with not being able to focus as well or is it safe to take stimulents with a Prolapse

  13. Tom Lamb Avatar

    Thank you for your Comment.
    Please understand the because I am not a physician I cannot answer your medical questions.
    I wish you the best in all aspects going forward.
    Tom Lamb

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